Circulatory System Archive

A 2025 randomized controlled trial found that GLP-1 receptor agonists, the blockbuster drugs approved to treat diabetes and obesity, boosted the walking ability of people with diabetes and peripheral artery disease (PAD) in the legs. The news is encouraging, since there are few effective treatments for PAD—reduced blood flow in the limbs that leads to pain with activity. However, it will take more evidence before doctors feel comfortable prescribing GLP-1s if a person only has PAD.

Fatty plaque that accumulates in the arteries of the legs, known as peripheral artery disease (PAD), can cause a painful, crampy sensation in the legs during walking. Smoking, obesity, diabetes, high blood pressure, and elevated cholesterol increase the risk of PAD, which affects nearly one in three people over age 75. Beyond quitting smoking, regular walking is the best treatment for PAD. A 2025 study found that semaglutide (Ozempic, Wegovy) may help people with PAD walk farther with less pain.

People with very high calcium scores (over 1,000) have a risk of heart attack or stroke similar to those who have already had a heart attack. They should take cholesterol-lowering drugs to bring down LDL levels and possibly undergo additional testing.