Cancer Archive

Research we're watching

Previous studies have suggested that being somewhat overweight or even slightly obese may not be associated with a shortened life span. Some studies have suggested that being a bit overweight might even be healthier than being at normal weight. This has been referred to as the "obesity paradox."

A recent analysis of data from the Nurses' Health Studies I and II and the Health Professionals Follow-up Study has helped bring clarity to this paradox. Researchers from the Harvard T.H. Chan School of Public Health and Boston University School of Public Health assessed the maximum body mass index (BMI) over 16 years for more than 190,000 postmenopausal women and 35,000 senior men. They then tracked who died over a follow-up period averaging 12 years. They found that people with a maximum BMI in the normal range (18.5 to 24.9 kg/m2) throughout life had the lowest risk of death. Those whose highest recorded BMI fell into the overweight or obese category were at elevated risk of dying from any cause, as well as dying specifically from cardiovascular disease, cancer, or respiratory disease, during the follow-up period.

Research we're watching

The FDA's medical device reporting program recently announced that as of February 1, it had received 359 reports of anaplastic large cell lymphoma (ALCL), a rare type of non-Hodgkin's lymphoma, in women who had received breast implants. Nine women had died of the disease. The FDA uses such reports to alert clinicians about potential significant side effects from approved drugs and devices, and as it gathers more information, the data may change. Many reports contained details of the implants, including whether the outside surface was smooth or textured and whether the filling was silicone gel or saline.

ALCL is usually found within a capsule of fibrous scar tissue that forms around an implant, not in the breast tissue itself. It appears to develop more frequently in women with textured implants, regardless of filling type.

The recommended guidelines for whether men should have the prostate cancer screening test have changed in recent years. A man considering the test should talk with his doctor and understand all the pros and cons involved.

Ask the doctors

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Q. I like gel manicures because the polish doesn't chip easily, but I've heard that they may cause cancer. Is this true?

A. The gel polish itself hasn't been associated with an increased risk of cancer. However, lamps and light boxes, which are used to seal the polish during professional manicures, have raised concern. That's because many emit fairly high levels of UVA radiation, which plays a major role in the development of cancer. The level of risk depends on the frequency of manicures. A 2014 study in JAMA Dermatology indicated that the level of UVA exposure associated with a gel manicure every two weeks probably isn't high enough to increase the risk of skin cancer significantly.

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Carrying around extra weight is a known risk factor for developing some cancers. But exactly which kinds of cancer are associated with obesity is debated. A study published Feb. 28, 2017, in The BMJ aimed to narrow it down. European researchers combed through about 100 large reviews of observational studies that looked for links between being overweight and getting cancer.

Out of 36 kinds of cancer evaluated, the researchers found strong evidence for a link to obesity for 11—in the colon, rectum, biliary tract (liver and gallbladder), pancreas, breast, endometrium (uterine lining), ovary, kidney, and the gastric cardia (the junction of the esophagus and stomach); a certain type of esophageal cancer (adenocarcinoma); and one type of bone marrow cancer (multiple myeloma). The researchers said there may be links between obesity and other cancers, but so far the evidence is relatively weak.

The earlier one starts tanning, the longer the lifetime skin damage and the higher the skin cancer risk. As the number of people with skin cancer increases, it has become especially important to convey to teenagers the message that tanning is an unhealthy choice, whether it’s outdoors or in a tanning bed.

Ask the doctor

Q. I smoked for more than 20 years, but gave it up about 15 years ago. Am I still at risk for lung cancer or other health problems?

A. Not smoking is the best health move any man can make. The good news is that the benefits of quitting smoking begin almost immediately after your final cigarette, although the risk of smoking-related cancers may take years to decline.